Our research focuses on the rational design and directed evolution of proteins and metabolic pathways to enhance catalytic efficiency, stability, and biological function.

Research Focus

• Protein engineering and enzyme optimization
• Directed evolution strategies
• Metabolic pathway design and reconstruction
• Systems-level analysis of cellular metabolism

Overview

We combine experimental biochemistry with computational tools to design and optimize enzymes and metabolic systems. By integrating rational design with high-throughput screening, we develop advanced biocatalysts with improved performance for industrial and biomedical applications.

Our work bridges molecular-level modifications with system-wide metabolic responses, enabling efficient engineering of biological systems.

Approaches and Methods

• Directed evolution and mutagenesis
• High-throughput screening (FACS, microfluidics)
• Protein structure–function analysis
• Computational modeling and bioinformatics

Applications

• Biocatalysis and green chemistry
• Synthetic biology
• Biomedical enzyme design
• Industrial biotechnology

Collaborations

We are open to collaborations in protein engineering, metabolic design, and applied biocatalysis. Please contact us for research partnerships and student opportunities.